Sandro Gozi studied Law in Bologna and International Relations at the Institut d'Études Politiques de Paris and holds a Master's degree in International Relations from the Université Libre de Bruxelles. He also holds a doctorate in public law from the University of Bologna.

Former diplomat, he also tought European Politics and Institutions in several European and American Universities. He worked 10 years in the European Commission and from 2000 to 2004 He was member of the cabinet of Commission President Romano Prodi. In 2006, he was appointed advisor on European affairs to the President of the Italian Council of Ministers, and between 2006 and 2013 he was member of the Chamber of Deputies and leader of the Democratic Party's parliamentary group on the European Union Policy Committee. He also chaired the Immigration and Schengen Parliamentary Committee. He was president of the Italian Delegation and vice-president of the Parliamentary Assembly of the Council of Europe.

He has served as Italian Secretary of State for European Affairs under the Renzi and Gentiloni governments (2014-2018) and was subsequently appointed advisor to the former French Prime Minister Edouard Philippe in 2019.

He has been decorated with the french orders of "Chevalier de la Légion d'Honneur” and “Officier des Palmes Académiques” and he holds a Doctorate Honoris Causa in Literature and Philosophy of the University of Fribourg.

Elected in 2019 in France, Sandro Gozi is today a Member of the European Parliament in the Renew Europe Group, Renew coordinator in the Committee on Constitutional Affairs and member of the Committee on the Internal Market and Consumer Protection and of the Committee of Regional Development. He is also Secretary General of the European Democratic Party. On 8 March 2024, he was nominated as the EDP's lead candidate at the Florence Convention.